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Proteomics is an interdisciplinary field that studies proteomes, or the complete set of proteins expressed by an organism. With the advent of high-throughput technologies such as mass spectrometry, researchers can now generate vast amounts of proteomic data, which requires computational tools to analyze and interpret. This is where Python comes in handy.
In this beginner’s guide, we will introduce you to Python proteomics using Biopython, a popular open-source toolkit for bioinformatics. We will cover basic concepts and techniques, including protein sequence manipulation, multiple sequence alignment, and functional annotation. By the end of this article, you should have a solid foundation for further exploration of Python proteomics.
Installing Biopython
Before diving into Python proteomics, let’s install Biopython first. You can do so via pip, the package manager for Python, with the following command:
pip install biopython
Once installed, verify your installation by running the following script:
from Bio import __version__…